Michael Thomas Henderson

CEO · Spyre Therapeutics, Inc.

Rank #790 SEC EDGAR (United States) ↗ Files from United States

Details

Officer and board memberPharmaceuticals & BiotechnologySYRESEC CIK 0001779990

Computed from SEC EDGAR filings and closing prices — not copied from any wealth ranking. Dataset . How we calculate this.

Disclosed holdings
$170.7M
1-day change
▲ 0.16%
Positions on file
2
issuers disclosed in Forms 3/4/5 and Schedules 13D/G

Disclosed holdings over time 53 weekly points

What the 1 currently disclosed position would have been worth at each week’s closing price. A rising line means the shares got more valuable, not that this person bought more.

How the line is built

Share counts are as last reported to the SEC and held constant; only prices move.

2025-09-05$2.5M – $18.0M2026-09-04

Insider activity Jul 5, 2024 – Mar 11, 2026

Michael Thomas Henderson is recorded in filings to the U.S. SEC via EDGAR as officer and board member, and reported 40 transactions between Jul 5, 2024 and Mar 11, 2026. The buy and sell totals below count only codes P, S.

Why the other codes are excluded

Share awards (A), shares withheld to pay tax (F), option exercises (M) and gifts (G) also appear in the table, but they are consequences of a pay package or a private transfer, not a decision to buy or sell on the open market. Counting them would turn this into a compensation ranking.

Open-market buys (code P)
None
0 purchases on file
Open-market sales (code S)
$19.72M
37 sales on file priced rows only
All reported transactions
40
every code, including awards and exercises
Pattern
Net seller in the final 12 months of the window
last 12 months of the window

Events from filings

Detected automatically in the filings linked below. Each headline is built from the numbers in those filings, not written by a model. Newest first; events older than 45 days stay listed and are marked as older.

Michael Thomas Henderson sold 80,000 Apogee Therapeutics, Inc. (APGE) shares for $10,603,200 on Jun 22, 2026

Large trade for this person

Flagged because this trade was large compared with this person’s own earlier open-market trades in the same currency — not because it is large in absolute terms. A trade that is routine for one insider can be flagged for another.

Michael Thomas Henderson sold 80,000 Apogee Therapeutics, Inc. (APGE) shares for $10,603,200 on Jun 22, 2026
Date Insider Transaction Shares Price Value Filing
Jun 22, 2026 Michael Thomas Henderson S Open-market sale 80,000 held after: 1,015,987 $132.54 $10,603,200 SEC filing ↗

Source: SEC EDGAR (United States); every row links to where it was published. Event computed Sep 14, 2026.

Michael Thomas Henderson sold 20,000 Spyre Therapeutics, Inc. (SYRE) shares for $2,000,000 on Jun 22, 2026

Unusual change in a direct holding

Flagged because the change that day in the shares this person holds directly was unusually large compared with their own earlier changes. The rows below are the open-market trades reported that day; under each share count is the balance the filing reports after that line.

Michael Thomas Henderson sold 20,000 Spyre Therapeutics, Inc. (SYRE) shares for $2,000,000 on Jun 22, 2026
Date Insider Transaction Shares Price Value Filing
Jun 22, 2026 Michael Thomas Henderson S Open-market sale 20,000 held after: 68,606 $100.00 $2,000,000 SEC filing ↗

Source: SEC EDGAR (United States); every row links to where it was published. Event computed Sep 14, 2026.

Michael Thomas Henderson sold 80,000 Spyre Therapeutics, Inc. (SYRE) shares for $5,952,050 on May 8, 2026

Unusual change in a direct holding

Flagged because the change that day in the shares this person holds directly was unusually large compared with their own earlier changes. The rows below are the open-market trades reported that day; under each share count is the balance the filing reports after that line.

Michael Thomas Henderson sold 80,000 Spyre Therapeutics, Inc. (SYRE) shares for $5,952,050 on May 8, 2026
Date Insider Transaction Shares Price Value Filing
May 8, 2026 Michael Thomas Henderson S Open-market sale 2,404 held after: 166,202 $72.57 $174,458 SEC filing ↗
May 8, 2026 Michael Thomas Henderson S Open-market sale 33,513 held after: 132,689 $73.72 $2,470,578 SEC filing ↗
May 8, 2026 Michael Thomas Henderson S Open-market sale 24,814 held after: 107,875 $74.76 $1,855,095 SEC filing ↗
May 8, 2026 Michael Thomas Henderson S Open-market sale 19,269 held after: 88,606 $75.35 $1,451,919 SEC filing ↗

Total of the rows above: $5,952,050, in the currency the filings report.

Source: SEC EDGAR (United States); every row links to where it was published. Event computed Sep 14, 2026.

Reported transactions

Price 0.00 is a real reported figure on gifts (G) and share awards (A) — not a missing number. The 25 most recent rows are grouped into 12 lines by date, company and transaction type — open a line to see every lot with its own source link. We hold 61 on file in total. See the full history on EDGAR ↗

How to read this list

Every row is one line of one Form 4 or Form 5, with the filing it came from. Where the record carries no price at all we leave the cell empty instead of guessing one.

The shares and money on a grouped line add up only the lots listed inside that line, and only when every one of them carries the figure. Where a group mixes more than one reporting currency we leave the money blank rather than convert — no source publishes the rate that conversion would need.

  1. Apogee Therapeutics, Inc. APGE D Disposition to the issuernot a buy/sell decisionreported at zero 920,941 shares $0 at $0.00 SEC filing ↗
  2. Apogee Therapeutics, Inc. APGE G Bona fide giftnot a buy/sell decisionreported at zero 75,046 shares $0 at $0.00 SEC filing ↗
  3. Apogee Therapeutics, Inc. APGE S Open-market sale 20,000 shares $2.67M at $133.63 SEC filing ↗
  4. Apogee Therapeutics, Inc. APGE S Open-market sale 80,000 shares $10.60M at $132.54 SEC filing ↗
  5. Spyre Therapeutics, Inc. SYRE S Open-market sale 20,000 shares $2.00M at $100.00 SEC filing ↗
  6. Apogee Therapeutics, Inc. APGE S Open-market sale × 6 20,000 shares $1.67M
    The 6 lots that make up this line, each with the source behind it.
    Shares Price Value Filing
    614 $86.89 $53.4K SEC filing ↗
    2,305 $86.27 $198.9K SEC filing ↗
    1,577 $85.19 $134.3K SEC filing ↗
    1,080 $84.18 $90.9K SEC filing ↗
    7,654 $82.78 $633.6K SEC filing ↗
    6,770 $82.21 $556.6K SEC filing ↗
  7. Apogee Therapeutics, Inc. APGE S Open-market sale × 2 20,000 shares $1.64M
    The 2 lots that make up this line, each with the source behind it.
    Shares Price Value Filing
    1,341 $82.58 $110.7K SEC filing ↗
    18,659 $82.05 $1.53M SEC filing ↗
  8. Spyre Therapeutics, Inc. SYRE S Open-market sale × 4 80,000 shares $5.95M
    The 4 lots that make up this line, each with the source behind it.
    Shares Price Value Filing
    19,269 $75.35 $1.45M SEC filing ↗
    24,814 $74.76 $1.86M SEC filing ↗
    33,513 $73.72 $2.47M SEC filing ↗
    2,404 $72.57 $174.5K SEC filing ↗
  9. Apogee Therapeutics, Inc. APGE M Option exercise or conversionnot a buy/sell decision 3,000 shares $68.6K at $22.86 SEC filing ↗
  10. Apogee Therapeutics, Inc. APGE S Open-market sale × 3 20,000 shares $1.65M
    The 3 lots that make up this line, each with the source behind it.
    Shares Price Value Filing
    200 $85.00 $17.0K SEC filing ↗
    2,000 $83.26 $166.5K SEC filing ↗
    17,800 $82.48 $1.47M SEC filing ↗
  11. Apogee Therapeutics, Inc. APGE S Open-market sale × 3 20,000 shares $1.50M
    The 3 lots that make up this line, each with the source behind it.
    Shares Price Value Filing
    8,363 $74.29 $621.3K SEC filing ↗
    8,219 $74.83 $615.0K SEC filing ↗
    3,418 $75.86 $259.3K SEC filing ↗
  12. Apogee Therapeutics, Inc. APGE S Open-market sale 7,551 shares $481.2K at $63.73 SEC filing ↗

Disclosed holdings

Shares is the amount on the form; value is that amount times the closing price shown. Rows with no closing price are left blank, so they may add up to less than the headline figure.

What is not counted here

Each row is one filing you can open. Private companies, real estate, bonds and crypto are not in SEC insider filings and are therefore not counted here.

Equity positions disclosed to the SEC, with the source filing behind each row.
Issuer Ticker Security Shares Close Value Form Reported Filing
Spyre Therapeutics, Inc. SYRE Common Stock 168,606 $88.98 $15.0M 4 EDGAR ↗
Apogee Therapeutics, Inc. APGE Common Stock 1,152,987 — — 4 EDGAR ↗

Other insiders at the same companies

People who also file with the SEC at a company where Michael Thomas Henderson reports shares.

Sharing a filing does not mean they work together day to day — it means both names appear on the same issuer’s insider record.

Sources

The filings linked in the tables above are the sources for every figure on this page.

Think a number here is wrong? Open the linked filing and compare — how to report it.

Profile record last refreshed Sep 8, 2026.